Hospital interior space design is a classic expression of how rationality and sensibility, function and emotion combined with each other organically. It takes care of people in a specific condition. We not only designed a clear streamline organization to satisfy the complex machine-like function of hospital architecture, but also create a humanized living environment that provide doctors, patients and visitors with a comfortable and warm atmosphere. Cultural Implantation: Shanghai East Hospital introduced natural and orient elements: porcelain, ink wash painting and typical color to transmit Chinese culture and the concept of “Unity of human and nature”. Main intention of this project is to seek the coziness of Oriental yard in the modern urban skyscraper. Humanization: In ward, a wrapped protection space that centralize the bed was built. Natural texture and soft color were coordinated to define the warmth of the space, and took people’s five senses into consideration. In contrast, washroom has a lively color and was classified as functional space. Dynamic Lighting Mode: According to the latest outcome of the physiology study and combined with human’s circadian rhythm, 24 hour dynamic lighting mode was designed to incorporate with different scene to accompany people and to help patient to recover.